Founded by Prof. Kristyn Masters in 2004, the Masters lab employs techniques from biomaterials, tissue engineering, bioconjugate chemistry, gene editing, and microfabrication, to create in vitro environments that model disease progression. We then apply molecular and cellular biology and computational tools to examine cell/tissue outcomes in these biomimetic culture platforms. Through this approach, we seek to: 1) understand how cells integrate multiple cues to make ‘decisions’ about their fate, and 2) decipher disease pathogenesis and elucidate the key stimuli involved, with the intent of using this knowledge to inform the design of clinical therapies. We have a particular interest in the extracellular matrix, cardiovascular disease, and sex differences.
After 19 years at the University of Wisconsin-Madison, the Masters Lab moved to the University of Colorado-Denver | Anschutz Medical Campus in June, 2023! Prof. Masters is now Chair of Bioengineering and Director of the Center for Bioengineering at CU-Denver|Anschutz.
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